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Medicine & Science in Sports & Exercise:
Clinical Sciences: Clinical Investigations

Effect of Ipratropium Bromide on EIB in Children Depends on Vagal Activity

KNÖPFLI, BRUNO H.1; BAR-OR, ODED2; ARAÚJO, CLAUDIO G. S.3

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Abstract

Purpose: Ipratropium bromide (IB) has been used to prevent exercise-induced bronchoconstriction (EIB), but its effect varies among individuals. We hypothesized that such variability may reflect individual differences in vagal activity (VA), and therefore determined whether a correlation exists between VA and the effect of IB on EIB in 13.0 (±0.8)-yr-old children with asthma and documented EIB.

Methods: Subjects served as their own control and were tested on three occasions in an ambient temperature of 5°C. Visit I included no treatment. In visits II and III (counterbalanced sequence) subjects inhaled either 500 μg IB or 0.9% NaCl as a placebo, 45 min before exercise provocation. Investigators and the subjects were blinded to the inhaled substance. VA was assessed by a 4-s exercise test (3). The ratio of resting ECG R-R-interval at full inspiration to the lowest R-R interval during 4-s cycling was taken as an index of VA. Eight-minute cycling at constant work rate (HR = 173 ± 4 bpm) at 5°C was used to provoke EIB. A two-factor (treatment × time) repeated-measures ANOVA was used.

Results: The exercise-induced drop in FEV1 was similar in the three sessions. However, because the IB caused a 15.7 ± 4.1 increase in FEV1 preexercise, the postexercise values after a placebo or no treatment were consistently lower than after IB. The beneficial response to IB, compared with no treatment and with placebo, was positively correlated to VA (for FEV1: r = 0.91, P = 0.002; and r = 0.90, P = 0.002, respectively).

Conclusion: We suggest that the therapeutic effect of IB on exercise-induced asthma may be related to vagal activity.

©2005The American College of Sports Medicine

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