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Effects of Oral ATP Supplementation on Anaerobic Power and Muscular Strength

JORDAN, ALEXANDER N.1; JURCA, RADIM1; ABRAHAM, EDWARD H.2; SALIKHOVA, ANNA2; MANN, JULIA K.1; MORSS, GINA M.1; CHURCH, TIMOTHY S.1; LUCIA, ALEJANDRO3; EARNEST, CONRAD P.1

Medicine & Science in Sports & Exercise: June 2004 - Volume 36 - Issue 6 - p 983-990
doi: 10.1249/01.MSS.0000128198.97260.8B
BASIC SCIENCES: Original Investigations

JORDAN, A. N., R. JURCA, E. H. ABRAHAM, A. SALIKHOVA, J. K. MANN, G. M. MORSS, T. S. CHURCH, A. LUCIA, and C. P. EARNEST. Effects of Oral ATP Supplementation on Anaerobic Power and Muscular Strength. Med. Sci. Sports Exerc., Vol. 36, No. 6, pp. 983–990, 2004.

Purpose: We examined 14 d of oral adenosine 5′-triphosphate (ATP) supplementation on indices of anaerobic capacity and muscular strength.

Methods: Twenty-seven healthy males successfully completed the trial, after randomly receiving in a double-blind manner an oral dose of low dose (150 mg) or high dose (225 mg) ATP, or matched placebo. To improve absorption characteristics, the ATP was enterically coated. Total blood ATP (whole blood and plasma ATP) concentrations, two Wingate anaerobic power tests (30 s), and muscular strength (1RM and three sets of repetitions to fatigue at 70% of 1RM) were measured under three conditions: (i) baseline; (ii) acutely (7d later, no prior supplementation and 75 min after ATP ingestion); and (iii) after 14 d of daily ingestion (post).

Results: Statistical analyses showed no significant between or within group treatment effects for whole blood ATP or plasma ATP concentrations for any treatment condition. We also did not observe any treatment effects for any Wingate testing parameter including peak PO, total work, average PO for 30 s, or post-Wingate lactate accumulation. Overall, we observed no significant between group treatment effects for any muscular strength parameter. We did observe several within group differences for the group ingesting the high ATP dosage including 1RM (6.6%; P < 0.04) and repetitions to fatigue during set 1 of posttesting (18.5%; P < 0.007) and total lifting volume at post (22%; P < 0.003).

Conclusions: We conclude that enterically coated oral ATP supplementation may provide small ergogenic effects on muscular strength under some treatment conditions.

1The Cooper Institute Centers for Integrated Health Research, Center for Human Performance and Nutrition Research, Dallas, TX; 2Radiation Oncology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Dartmouth Medical School, Hanover, NH; and 3Exercise Physiology Laboratory, European University of Madrid, SPAIN

Address for correspondence: Conrad P. Earnest, Ph.D., FACSM, Director, Center for Human Performance and Nutrition Research, The Cooper Institute, Centers for Integrated Health Science Research, 12330 Preston Road, Dallas, TX 75230; E-mail: cearnest@cooperinst.org.

Submitted for publication November 2003.

Accepted for publication February 2004.

©2004The American College of Sports Medicine