Beta-blockers, exercise, and the immune system in men with coronary artery disease


Medicine & Science in Sports & Exercise: April 2002 - Volume 34 - Issue 4 - pp 587-591
CLINICAL SCIENCES: Clinically Relevant

SAGIV, M., D. BEN-SIRA, and E. GOLDHAMMER. Beta-blockers, exercise, and the immune system in men with coronary artery disease. Med. Sci. Sports Exerc., Vol. 34, No. 4, pp. 587–591, 2002.

Purpose: The purpose of the present study was to examine the effect of aerobic exercise training on the immune system in coronary artery disease patients treated with β-blockers.

Methods: Twenty-five patients (46.1 ± 2 yr) treated with atenolol, a β-blocker agent, for 3 months before exercising were divided randomly into two groups: 15 underwent an aerobic exercise training program for 12 wk at 65–70% of their work capacity, whereas the other 10 patients served as controls.

Results: After training, levels of CD4 and CD8 cells were significantly (P < 0.05) higher and concomitantly the CD4/CD8 ratio decreased significantly (P < 0.05) in the exercising group compared with the control group.

Conclusions: Data suggest that coronary artery disease patients exercising aerobically at 65–70% of their work capacity gain a statistically significant higher lymphocyte T cell function as compared with their untrained counterparts.

The Sports Medicine and Rehabilitation Division, The Zinman College at Wingate, ISRAEL; and Heart Institute Bnai-Zion Haifa Medical Center, ISRAEL

Submitted for publication September 2000.

Accepted for publication August 2001.

©2002The American College of Sports Medicine