Skip Navigation LinksHome > September 2001 - Volume 33 - Issue 9 > Role of airway receptors in altitude-induced dyspnea
Medicine & Science in Sports & Exercise:
CLINICAL SCIENCES: Clinically Relevant

Role of airway receptors in altitude-induced dyspnea

MANSOOR, JIM K.; ELDRIDGE, MARLOWE W.; YONEDA, KEN Y.; SCHELEGLE, ED S.; WOOD, STEVE C.

Collapse Box

Abstract

MANSOOR, J. K., M. W. ELDRIDGE, K. Y. YONEDA, E. S. SCHELEGLE, and S. C. WOOD. Role of airway receptors in altitude-induced dyspnea. Med. Sci. Sports Sci., Vol. 33, No. 9, 2001, pp. 1449–1455.

Purpose: The purpose of this study was to examine the role of airway receptors in respiratory-related sensations after ascent to altitude.

Methods: Ratings of respiratory-related sensations, perceived exertion and acute mountain sickness, heart rate, and peripheral oxygen saturation were recorded at rest and exercise in male and female subjects who had inhaled either aerosolized saline or saline with tetracaine after acute ascent to an altitude of 3500 m and after prolonged acclimatization of 18 d at altitudes between 4000 and 5000 m.

Results: Tetracaine had no effect on respiratory-related sensations at altitude either at rest or during exercise, and male and female subjects experienced similar respiratory-related sensations. Sensations of rapid breathing were experienced at rest after acute exposure to 3500 m as compared with sea level, but not after acclimatization to 5000 m. Sensations of rapid breathing, air hunger, and heavy breathing were experienced during exercise after acute and prolonged altitude exposure as compared with sea level, with a sensation of chest tightness experienced at 3500 m and a sensation of gasping experienced at 5000 m.

Conclusion: These results suggest that airway afferents play no role in the respiratory-related sensations experienced by male and female subjects either during acute ascent to altitude or after prolonged acclimatization at altitude.

© 2001 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us