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Medicine & Science in Sports & Exercise:
Clinical Sciences: Clinically Relevant

The effect of prolonged exercise on lipid peroxidation in eumenorrheic female runners

CASE, DOROTHY; BAER, JANINE T.; SUBBIAH, M. T. R.

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Abstract

CASE, D., J. T. BAER, and M. T. R. SUBBIAH. The effect of prolonged exercise on lipid peroxidation in eumenorrheic female runners. Med. Sci. Sports Exerc., Vol. 31, No. 10, pp. 1390–1393, 1999.

Purpose: Recently a protective role has been demonstrated for estrogens as free radical scavengers. In this study, lipid peroxidation was evaluated in eumenorrheic runners before and after participation in a half-marathon.

Methods: Seven female runners who participated in regular training (average 25 miles·wk−1) and reported regular menses (12/yr) served as subjects. Subjects were all in a low estrogen phase of their menstrual cycle as confirmed by menstrual record and plasma estradiol level (42.71 ± 21.65 pg·mL−1). Low density lipoprotein oxidation (formation of conjugated dienes) was determined 2 h prerace and 5 min after subject’s completion of the race.

Results: Results showed a significant increase in lag phase time of conjugated dienes after prolonged exercise (28.43 ± 4.89 min vs postrace 35.21 ± 4.32 min, P < 0.05). No correlation between mean levels of estradiol and mean lipid peroxidation levels at rest, 5 min after exercise, or difference (prepost) was observed.

Conclusion: Prolonged endurance exercise does not appear to increase potential for lipid peroxidation in trained eumenorrheic runners during a low estrogen phase of the menstrual cycle.

© 1999 Lippincott Williams & Wilkins, Inc.

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