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Medicine & Science in Sports & Exercise:
Basic Sciences: Original Investigations

Effects of intermittent ischemia on contractile properties and myosin isoforms of skeletal muscle

DODD, STEPHEN L.; VRABAS, IOANNIS S.; STETSON, DANIEL S.

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Abstract

Effects of intermittent ischemia on contractile properties and myosin isoforms of skeletal muscle. Med. Sci. Sports Exerc., Vol. 30, No. 6, pp. 850-855, 1998.

Purpose: This study determined the effects of intermittent ischemia on the contractile properties, fatigue (Tf), and myosin heavy chain composition (MHC) in the rat gastrocnemius-plantarissoleus muscle (GPS) complex.

Methods: Fifty rats were divided into four groups: control (C, N = 12), severed (femoral artery) (S, N = 12), exercise (E, N = 13), and severed/exercise (SE, N = 13). Ischemia was elicited only in the SE group by daily exercise and the other groups served as controls. Exercise in the E and SE groups consisted of running on a treadmill ∼ 35 min·d−1, 5 d·wk−1 for 7 wk.

Results: Body weight, muscle weight, and absolute force were less in the SE group compared with those in C (12, 18, and 12% respectively). However, relative force (N·g−1 of muscle) was greater in the SE group compared with that in C (8%). Maximal shortening velocity (Vmax) was lower in the SE group compared with that in all others (10-14%). Tf was less in the S group compared with that in C and E (28 and 30%, respectively). Type IIx MHC increased and type IIb decreased in gastrocnemius and plantaris muscles in SE compared with those in C.

Conclusions: These data indicate that intermittent ischemia caused a decrease in muscle mass, maximal force development, and Vmax, but had no effect on Tf. The decrease in Vmax may have been related to myosin alterations in the muscles.

© Williams & Wilkins 1998. All Rights Reserved.

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