Effect of resistance exercise on free radical production

McBRIDE, JEFFREY M.; KRAEMER, WILLIAM J.; TRIPLETT-McBRIDE, TRAVIS; SEBASTIANELLI, WAYNE

Medicine & Science in Sports & Exercise: January 1998 - Volume 30 - Issue 1 - pp 67-72
Basic Sciences: Original Investigations

The purposes of this investigation were to see whether free radical production changed with high intensity resistance exercise and, secondly, to see whether vitamin E supplementation would have any effect on free radical formation or variables associated with muscle membrane disruption. Twelve recreationally weight-trained males were divided into two groups. The supplement group (S) received 1200 IUs of vitamin E once a day (3 × 400 IU·d-1) for a period of 2 wk. The placebo group (P) received cellulose-based placebo pills once a day for the same period of time. Creatine kinase activity was significantly elevated between preexercise and immediately postexercise, 6 h postexercise, and 24 h postexercise for both groups. The placebo group also had a significant increase in creatine kinase activity at 48 h postexercise. There was a significant difference in creatine kinase activity between the groups at 24 h after exercise. Plasma malondialdehyde significantly increased from preexercise levels for the P group at 6 and 24 h postexercise. Plasma malondialdehyde concentrations significantly increased in the S group between preexercise and immediately postexercise levels. This study indicates that high intensity resistance exercise increases free radical production and that vitamin E supplementation may decrease muscle membrane disruption.

Laboratory for Sports Medicine/Department of Kinesiology, Noll Physiological Research Center, Center for Sports Medicine, Center for Cell Research, The Pennsylvania State University, University Park, PA 16802

Submitted for publication February 1997.

Accepted for publication August 1997.

©1998The American College of Sports Medicine