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Medicine & Science in Sports & Exercise:
Basic Sciences: Symposium: Metabollic Adaptations to Endurance Training: Recent Advances

Effect of endurance training on ammonia and amino acid metabolism in humans

GRAHAM, TERRY E.; TURCOTTE, LAURAINE P.; KIENS, BENTE; RICHTER, ERIK A.

Section Editor(s): Coggan, Andrew R. Chair

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Abstract

Few studies examine ammonia and amino acid metabolism in response to endurance training. Trained humans generally experience less increase in plasma ammonia during either prolonged or intense exercise. This is probably a reflection of reduced ammonia production and release from the active muscle; it could be a reflection of decreased AMP deaminase activity, decreased glutamate dehydrogenase activity, and/or increased alanine and glutamine formation. Little is known regarding the associated enzyme systems in humans, but in experiments with animal models, aerobic training decreases AMP deaminase and increases the enzymes of amino acid transmination and oxidation.

©1997The American College of Sports Medicine

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