Effects of altered loading states on muscle plasticity: what have we learned from rodents?


Medicine & Science in Sports & Exercise: October 1996 - Volume 28 - Issue 10 - pp 101-106
International Workshop on Cardiovascular Rearch in Space: Integrated Physiology of [mu]G

This paper summarizes the key findings concerning the adaptive properties of rodent muscle in response to altered loading states. When the mechanical stress on the muscle is chronically increased, the muscle adapts by hypertrophying its fibers. This response is regulated by processes resulting in contractile protein expression reflecting slower phenotypes, thereby enabling the muscle to better support load-bearing activity. In contrast, reducing the load-bearing activity induces an opposite response whereby muscles used for both antigravity function and locomotion atrophy while transforming some of the slow fibers into faster contractile phenotypes. Accompanying the atrophy is both a reduced power generating and activity sustaining capability. These adaptive processes are regulated by both transcriptional and translational processes. Available evidence further suggests that the interaction of heavy resistance activity and hormonal/growth factors (insulin-like growth factor, growth hormone, glucocorticoids, etc.) are critical in the maintenance of muscle mass and function. Also resistance training, in contrast to other activities such as endurance running, provides a more economical form of stress because less mechanical activity is required to maintain muscle homeostasis in the context of chronic states of weightlessness.

Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92717

Submitted for publication December 1995.

Accepted for publication May 1996.

This paper was supported in part by NASA NAG2-555 and NIH AR 30346 and HL 38819.

Address for correspondence: Kenneth M. Baldwin, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92717.

©1996The American College of Sports Medicine