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The effect of endurance training on lipoprotein(a) [Lp(a)] levels in middle-aged males


Medicine & Science in Sports & Exercise: June 1996 - Volume 28 - Issue 6 - p 757-764
Applied Sciences: Physical Fitness and Performance

Serum lipoprotein(a) [Lp(a)] levels were measured before and after a 12-wk program of moderate-intensity endurance training. The training program consisted of walking and/or jogging, at least three sessions·wk-1 of at least 30 min duration, at an intensity producing 60-85% HRmax reserve. Twenty-eight previously sedentary middle-aged Caucasian males matched for age, body mass, and body mass index(BMI) were randomly allocated to either an exercise (N = 17, mean age ± SEM = 51.57 ± 1.25 yr) or a control (N = 11, mean age ± SEM = 50.0 ± 1.15 yr) group. Pre- and post-training median Lp(a) levels, measured by immunoturbidimetric analysis, were not significantly different in either the exercise (pre 13.0, post 15.0 mg·dl-1) or the control subjects (pre 14.0, post 12.0 mg·dl-1)(P > 0.05). Kendall Rank correlation analysis revealed no significant relationship between the level of Lp(a) and any other variable in either group before or after training. In the exercisers, a significant increase (P < 0.05) was recorded in the estimated mean ˙VO2max (pre 33.39 ± 1.70, post 37.7 ± 1.75 ml·kg-1·min-1). These data indicate that the level of Lp(a) was not influenced by a 12-wk program of moderate-intensity endurance training, and are consistent with previous reports suggesting that Lp(a) level is not altered by lifestyle factors.

Department of Human Movement Studies, The University of Queensland, Queensland 4072, AUSTRALIA

Submitted for publication June 1995.

Accepted for publication January 1996.

The authors acknowledge the advice and assistance given by Dr. Alf Howard in the statistical analysis of the study; and Dr. Charlie Appleton, Pathologist, and Mark Blakey, Biochemist, Queensland Medical Laboratory, West End, Brisbane, for assistance in the measurement of lipoproteins.

Address for correspondence: Dr. Laurel Traeger Mackinnon, Department of Human Movement Studies, The University of Queensland, Queensland 4072, Australia. E-mail:

©1996The American College of Sports Medicine