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Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms

Carter, Sophie; Hartman, Yvonne; Holder, Sophie; Thijssen, Dick H.; Hopkins, Nicola D.

Exercise and Sport Sciences Reviews: April 2017 - Volume 45 - Issue 2 - p 80–86
doi: 10.1249/JES.0000000000000106
Articles

Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.

Sedentary behavior modulates key stimuli that impair arterial health, directly and indirectly contributing to the development of cardiovascular disease.

1Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Liverpool, United Kingdom; and 2Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Address for correspondence: Nicola Hopkins, Ph.D., Research Institute for Sport and Exercise Science, Liverpool John Moore's University, Byrom Street, Liverpool L3 2ET, United Kingdom (E-mail: n.d.hopkins@ljmu.ac.uk).

Accepted for publication: January 10, 2017.

Editor: Donald R. Dengel, Ph.D., FACSM.

© 2017 American College of Sports Medicine