Low-capacity runner (LCR) and high-capacity runner (HCR) rat strains are divergent for running capacity and aerobic fitness. The LCR rats are susceptible to obesity, insulin resistance, and fatty liver whereas the HCR are protected. We performed studies testing the hypothesis that the divergence in susceptibility for obesity and metabolic dysfunction between HCR/LCR is due to differences in hepatic mitochondrial function that also may drive differences in energy expenditure and substrate usage.
High– and low–running capacity rats display differences in mitochondrial metabolism that drive differences in susceptibility for metabolic disease.
1Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS and 2Research Service, Kansas City VA Medical Center, Kansas City, MO
Address for correspondence: John P. Thyfault, Ph.D., Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 2067 Hemenway Life Sciences and Innovation Center, MS 3043, 3901 Rainbow Blvd, Kansas City, KS 66160 (E-mail: firstname.lastname@example.org).
Accepted for publication: June 30, 2016.
Associate Editor: Monica J. Hubal, Ph.D., FACSM.