Skip Navigation LinksHome > April 2014 - Volume 42 - Issue 2 > The Emerging Biomolecular Role of Vitamin D in Skeletal Musc...
Exercise & Sport Sciences Reviews:
doi: 10.1249/JES.0000000000000013
Articles

The Emerging Biomolecular Role of Vitamin D in Skeletal Muscle

Pojednic, Rachele M.1; Ceglia, Lisa2,3

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Abstract

In this review, we summarize current evidence for a direct effect of vitamin D on skeletal muscle. A number of studies identify the receptor for 1,25-dihydroxyvitamin-D3 (vitamin D receptor (VDR)) and the enzyme CYP27B1 (1-α-hydroxylase) in muscle. We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.

© 2014 American College of Sports Medicine

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