Potential Role of Branched-Chain Amino Acid Catabolism in Regulating Fat Oxidation

Kainulainen, Heikki1; Hulmi, Juha J.1; Kujala, Urho M.2

Exercise & Sport Sciences Reviews:
doi: 10.1097/JES.0b013e3182a4e6b6
Articles
Abstract

Insulin-resistant or obese individuals have increased serum branched-chain amino acid (BCAA) levels. Recent findings relate increased BCAA catabolism to increased fatty acid oxidation and better metabolic health in physically active individuals. We hypothesize that, via glyceroneogenesis, BCAA catabolism mediates increased constitutive use of fatty acids for β-oxidation in subjects with increased inherent or acquired aerobic capacity both during exercise and at rest.

In Brief

This article presents the hypothesis that skeletal muscle BCAA catabolism mediates increased constitutive use of fatty acids for β-oxidation.

Author Information

1Departments of Biology of Physical Activity, and 2Health Sciences, University of Jyväskylä, Jyväskylä, Finland

Address for correspondence: Heikki Kainulainen, Ph.D., Department of Biology of Physical Activity, University of Jyväskylä, P. O. Box 35, FI-40014 University of Jyväskylä, Jyväskylä, Finland (E-mail: heikki.kainulainen@sport.jyu.fi).

Accepted for publication: June 28, 2013.

Associate Editor: Barry Braun, Ph.D., FACSM

© 2013 American College of Sports Medicine