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Exercise and Nutrition to Target Protein Synthesis Impairments in Aging Skeletal Muscle

Dickinson, Jared M.1; Volpi, Elena2,3; Rasmussen, Blake B.2,4,5

Exercise & Sport Sciences Reviews: October 2013 - Volume 41 - Issue 4 - p 216–223
doi: 10.1097/JES.0b013e3182a4e699
Articles

The loss of skeletal muscle size and function with aging and sarcopenia may be related, in part, to an age-related muscle protein synthesis impairment. In this review, we discuss to what extent aging affects skeletal muscle protein synthesis and how nutrition and exercise can be used strategically to overcome age-related protein synthesis impairments and slow the progression of sarcopenia.

This review discusses how aging affects the protein synthesis response of skeletal muscle to nutrition and exercise.

1School of Nutrition and Health Promotion, Healthy Lifestyles Research Center, Exercise and Wellness Program, Arizona State Unversity, Phoenix, AZ, 2Sealy Center on Aging, 3Department of Internal Medicine-Geriatrics, 4Department of Nutrition and Metabolism, 5Division of Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX

Address for correspondence: Jared M. Dickinson, Ph.D., Arizona State University, School of Nutrition and Health Promotion, Healthy Lifestyles Research Center, Exercise and Wellness Program, 500 N. 3rd St., Phoenix, AZ 85004 (E-mail: jared.dickinson@asu.edu).

Accepted for publication: July 11, 2013.

Associate Editor: LaDora V. Thompson, Ph.D.

© 2013 American College of Sports Medicine