Skip Navigation LinksHome > July 2013 - Volume 41 - Issue 3 > Unraveling the Complexities of SIRT1-Mediated Mitochondrial...
Exercise & Sport Sciences Reviews:
doi: 10.1097/JES.0b013e3182956803
Articles

Unraveling the Complexities of SIRT1-Mediated Mitochondrial Regulation in Skeletal Muscle

Philp, Andrew1; Schenk, Simon2

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Abstract

Sirtuin 1 (SIRT1) is a purported central regulator of skeletal muscle mitochondrial biogenesis. Herein, we discuss our recent work using conditional mouse models, which highlight the complexities of SIRT1 biology in vivo, and question the role of SIRT1 in regulating mitochondrial function and mitochondrial adaptations to endurance exercise. Furthermore, we discuss the possible contribution of proposed SIRT1 substrates to muscle mitochondrial biogenesis.

© 2013 American College of Sports Medicine

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