Skip Navigation LinksHome > July 2013 - Volume 41 - Issue 3 > The Role of Nrf2 in the Attenuation of Cardiovascular Diseas...
Exercise & Sport Sciences Reviews:
doi: 10.1097/JES.0b013e3182948a1e
Articles

The Role of Nrf2 in the Attenuation of Cardiovascular Disease

Reuland, Danielle J.1; McCord, Joe M.2; Hamilton, Karyn L.1

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Abstract

Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.

© 2013 American College of Sports Medicine

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