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Exercise & Sport Sciences Reviews:
doi: 10.1097/JES.0b013e318275d230
Articles

From Anabolic to Oxidative: Reconsidering the Roles of IL-15 and IL-15Rα in Skeletal Muscle

Pistilli, Emidio E.1,2; Quinn, LeBris S.3,4

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Abstract

Interleukin 15 (IL-15) and its receptor IL-15 receptor-α (IL-15Rα) are suggested to function in the determination of skeletal muscle phenotypes, with IL-15 originally proposed as an anabolic cytokine. This review will focus on recent work demonstrating that manipulation of IL-15 and IL-15Rα in vivo promotes changes in exercise capacity, muscle fatigue, and gene expression indicative of a more oxidative skeletal muscle phenotype.

©2013 The American College of Sports Medicine

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