Skip Navigation LinksHome > January 2013 - Volume 41 - Issue 1 > Origin and Development of Muscle Cramps
Exercise & Sport Sciences Reviews:
doi: 10.1097/JES.0b013e3182724817
Articles

Origin and Development of Muscle Cramps

Minetto, Marco Alessandro1; Holobar, Aleš2; Botter, Alberto3; Farina, Dario4

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Abstract

Cramps are sudden, involuntary, painful muscle contractions. Their pathophysiology remains poorly understood. One hypothesis is that cramps result from changes in motor neuron excitability (central origin). Another hypothesis is that they result from spontaneous discharges of the motor nerves (peripheral origin). The central origin hypothesis has been supported by recent experimental findings, whose implications for understanding cramp contractions are discussed.

©2013 The American College of Sports Medicine

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