Skip Navigation LinksHome > October 2012 - Volume 40 - Issue 4 > Effect of Statins on Skeletal Muscle: Exercise, Myopathy, a...
Exercise & Sport Sciences Reviews:
doi: 10.1097/JES.0b013e31826c169e
Articles

Effect of Statins on Skeletal Muscle: Exercise, Myopathy, and Muscle Outcomes

Parker, Beth A.1,2,3; Thompson, Paul D.1,2

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Abstract

Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.

©2012 The American College of Sports Medicine

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