Mitochondria are dynamic organelles in skeletal muscle critical in physical performance and disease. The mitochondrial life cycle spans biogenesis, maintenance, and clearance. Exercise training may promote each of these processes, conferring positive impacts on skeletal muscle contractile and metabolic functions. This review focuses on the regulation of these processes by endurance exercise and discusses potential benefits in health and disease.
Increased mitochondrial quantity and quality underlie exercise training–induced adaptation. We examine these processes in skeletal muscle.
Departments of Medicine and Pharmacology, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908
Address for correspondence: Zhen Yan, PhD, Center for Skeletal Muscle Research, Robert M. Berne Cardiovascular Research Center, University of Virginia, 409 Lane Road, MR4 6041A, Charlottesville, VA 22908 (E-mail: firstname.lastname@example.org).
Accepted for publication: March 23, 2012.
Associate Editor: Stephen E. Alway, Ph.D., FACSM