This commentary focuses on the issues of statistical power, the usefulness of hypothesis-free approaches such as in genome-wide association explorations, the necessity of expanding the research beyond common DNA variants, the advantage of combining transcriptomics with genomics, and the complexities inherent to the search for links between genotype and phenotype in exercise genomics research.
High-quality research designs and replication studies with large sample sizes are needed if exercise genomics is to deliver on its promises.
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA
Address for correspondence: Claude Bouchard, Ph.D., John W. Barton, Sr. Endowed Chair in Genetics and Nutrition, Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 (E-mail:firstname.lastname@example.org).
Accepted for publication: May 20, 2011.
Associate Editor: Stephen M. Roth, Ph.D., FACSM