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Mitochondrial Protection by Resveratrol

Ungvari, Zoltan1; Sonntag, William E.1; de Cabo, Rafael2; Baur, Joseph A.3; Csiszar, Anna1

Exercise & Sport Sciences Reviews: July 2011 - Volume 39 - Issue 3 - pp 128-132
doi: 10.1097/JES.0b013e3182141f80
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Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.

Resveratrol exerts mitochondrial protective effects, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.

1Reynolds Oklahoma Center on Aging, Departments of Geriatric Medicine and Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; 2Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD; and 3Institute for Diabetes, Obesity, and Metabolism and Department of Physiology, Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Address for correspondence: Zoltan Ungvari, M.D., Ph.D., Reynolds Oklahoma Centeron Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 N. E. 10th Street, BRC 1303, Oklahoma City, OK 73104 (E-mail: zoltan-ungvari@ouhsc.edu).

Accepted for publication: February 3, 2011.

Associate Editor: LaDora V. Thompson, Ph.D.

©2011 The American College of Sports Medicine