We hypothesized that high-intensity aerobic interval training results in a greater beneficial adaptation of the heart compared with that observed after low-to-moderate exercise intensity. This is supported by recent epidemiological, experimental, and clinical studies. Cellular and molecular mechanisms of myocardial adaptation to exercise training are discussed in this review.
Health effects of exercise-induced cellular and molecular cardiovascular adaptation mechanisms are markedly larger in interval training at high relative intensity.
1Department of Circulation and Medical Imaging, Norwegian University of Science and Technology; 2Department of Cardiology, St. Olavs Hospital, Trondheim, Norway; and 3Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, United Kingdom
Address for correspondence: Ulrik Wisløff, Ph.D., Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway (E-mail: firstname.lastname@example.org).
Accepted for publication: March 4, 2009.
Associate Editor: Hirofumi Tanaka, Ph.D., FACSM