Exercise Physiology versus Inactivity Physiology: An Essential Concept for Understanding Lipoprotein Lipase Regulation

Hamilton, Marc T.1,2; Hamilton, Deborah G.1; Zderic, Theodore W.1

Exercise & Sport Sciences Reviews:
Articles
Abstract

HAMILTON, M.T., D.G. HAMILTON, and T.W. ZDERIC. Exercise physiology versus inactivity physiology: An essential concept for understanding lipoprotein lipase regulation. Exerc. Sport Sci. Rev., Vol. 32, No. 4, pp. 161–166, 2004. Some health-related proteins such as lipoprotein lipase may be regulated by qualitatively different processes over the physical activity continuum, sometimes with very high sensitivity to inactivity. The most powerful process known to regulate lipoprotein lipase protein and activity in muscle capillaries may be initiated by inhibitory signals during physical inactivity, independent of changes in lipoprotein lipase messenger RNA.

In Brief

Some health-promoting proteins like lipoprotein lipase may be regulated by qualitatively different processes over the physical activity continuum, with high sensitivity to inactivity.

Author Information

1Department of Biomedical Sciences and 2Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO

Address for correspondence: Marc T. Hamilton, Biomedical Sciences, 1600 East Rollins Road, University of Missouri, Columbia MO 65211 (E–mail: hamiltonm@missouri.edu).

Accepted for publication: June 29, 2004.

©2004 The American College of Sports Medicine