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Growth Hormone Molecular Heterogeneity and Exercise

Nindl, Bradley C.1; Kraemer, William J.2; Marx, James O.3; Tuckow, Alexander P.1; Hymer, Wesley C.4

Exercise & Sport Sciences Reviews: October 2003 - Volume 31 - Issue 4 - pp 161-166
Articles

NINDL, B. C., W. J. KRAEMER, J. O. MARX, A. P. TUCKOW, and W. C. HYMER. Growth hormone molecular heterogeneity and exercise. Exerc. Sport Sci. Rev., Vol. 31, No. 4, pp. 161–166, 2003. There are more than 100 molecular isoforms of circulating growth hormone (GH), but the traditional measurement approach in the exercise literature has only focused on the main isoform ( i.e., 22 kDa). New assay methodologies now can assess various GH isoforms. The current data suggest that exercise results in the preferential release of GH isoforms with extended half-lives, thereby sustaining biological actions.

Exercise induces alterations in the molecular isoforms of growth hormone (GH), which potentially enhances the biological activity of GH.

1Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA; 2The Human Performance Laboratory, Department of Kinesiology, The University of Connecticut, Storrs; and Departments of 3Kinesiology and 4Biochemistry and Molecular Biology, The Pennsylvania State University, University Park

Accepted for publication: June 23, 2003.

Address for correspondence: Bradley C. Nindl, Ph.D., FACSM, Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760 (E-mail: Bradley.nindl@na.amedd.army.mil).

©2003The Amercian College of Sports Medicine