Specific Genetic Markers of Endurance Performance and Vo2max

Hagberg, James M.1; Moore, Geoffrey E.2; Ferrell, Robert E.3

Exercise & Sport Sciences Reviews:

HAGBERG, J.M., G.E. MOORE, and R.E. FERRELL. Specific genetic markers of endurance performance and V̇o2max. Exerc. Sport Sci. Rev., Vol. 29, No. 1, pp 15–19, 2001. Recent advances have revolutionized genetic studies of quantitative traits. Mitochondrial DNA and creatine kinase variations may influence V̇o2max. Other data strongly suggest that angiotensin-converting enzyme genotype affects V̇o2max and endurance performance capacity, but the mechanisms are unclear. A recent genome-wide scan study also has provided candidate loci requiring further study.

Author Information

1Department of Kinesiology, University of Maryland, College Park, Maryland; 2Cardiovascular Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and 3Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania

Accepted for publication: June 28, 2000.

Address for correspondence: James Hagberg, Ph.D., Department of Kinesiology, University of Maryland, College Park, MD 20742 (E-mail: jh103@umail.umd.edu).

© 2001 Lippincott Williams & Wilkins, Inc.