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Some Pharmacokinetics of Sevoflurane in a Child with Severe Lipodystrophy

Steen, Evi R. MD; De Baerdemaeker, Luc E. C. MD, PhD, DEEA; Van Limmen, Jurgen MD; Wouters, Patrick MD, PhD

doi: 10.1097/ACC.0b013e3182a706f6
Case Reports: Case Report

Lipodystrophies are acquired or inherited disorders characterized in part by the selective loss of adipose tissue and hypertriglyceridemia. The present case report of 2 sevoflurane anesthetics given to a child with such a disorder, before and after correction of severe hypertriglyceridemia, illustrates the considerable effects of increased serum lipids and decreased fat stores on the pharmacokinetics of sevoflurane.

From the Department of Anesthesiology, University Hospital Ghent, Ghent, Belgium.

Accepted for publication July 16, 2013.

Funding: None.

The authors declare no conflicts of interest.

Address correspondence to Luc E. C. De Baerdemaeker, MD, PhD, DEEA, Department of Anesthesiology, University Hospital Ghent, Belgium, De Pintelaan 185, 9000 Gent. Address e-mail to

© 2014 International Anesthesia Research Society
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