Skip Navigation LinksHome > July 15, 2014 - Volume 3 - Issue 2 > Improving Awareness of Nonanesthesia-Related Malignant Hyper...
A&A Case Reports:
doi: 10.1213/XAA.0000000000000043
Case Reports: Case Report

Improving Awareness of Nonanesthesia-Related Malignant Hyperthermia Presentations: A Tale of Two Brothers

Potts, Lauren E. MD*; Longwell, Jason J. MD*; Bedocs, Peter MD; Sambuughin, Nyamkhishig PhD; Bina, Saiid PhD; Cooper, Patrick B. MD§; Carroll, Craig G. MD; O’Connor, Francis MD; Deuster, Patricia PhD; Muldoon, Sheila M. MD; Hamilton, Susan PhD**; Capacchione, John F. MD

Collapse Box

Abstract

A 30-year-old man developed unexplained rhabdomyolysis, persistently increased creatine kinase and severe debilitating muscle cramps. After a nondiagnostic neurologic evaluation, he was referred for a muscle biopsy, to include histology/histochemistry, a myoglobinuria panel, and a caffeine halothane contracture test. Only the caffeine halothane contracture test was positive, and a subsequent ryanodine receptor type 1 gene evaluation revealed a mutation functionally causative for malignant hyperthermia. His identical twin brother, who was suffering from similar complaints, was found to share the same mutation. They each require oral dantrolene therapy to control symptoms, despite difficulty in identifying health care providers familiar with treating this disorder.

© 2014 International Anesthesia Research Society

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Become a Society Member