Spinal cord stimulation is a treatment modality used to treat various chronic pain conditions, including complex regional pain syndrome (CRPS). We present a case in which spinal cord stimulation was used for the treatment of lower extremity CRPS in a patient with ankylosing spondylitis. Preoperative imaging demonstrated fusion of the lumbothoracic spine with obliteration of the interlaminar spaces. The sacral hiatus remained open and was used to access the epidural space, facilitating the placement of 2 thoracic epidural electrodes. The resulting stimulation controlled not only the patient’s lower extremity CRPS pain but also alleviated his chronic axial pain secondary to ankylosing spondylitis.