Skip Navigation LinksHome > April 1, 2014 - Volume 2 - Issue 7 > Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMD...
A&A Case Reports:
doi: 10.1213/XAA.0000000000000003
Case Reports: Case Report

Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis

Broderick, Daniel K. MD; Raines, Douglas E. MD; Nanji, Karen C. MD, MPH

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Abstract

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a recently identified syndrome characterized by psychosis and dysautonomia. Treatment includes resection of the underlying tumor. While the pathologic mechanism involves disruption of NMDA function by anti-NMDA receptor autoantibodies, there are few descriptions of the perioperative management or anesthetic approach for such patients. We report a classic presentation of anti-NMDA receptor encephalitis and describe the use of total IV anesthesia with NMDA receptor-sparing drugs. Modest postoperative analgesic requirements, not reported in prior cases, are also described in our report.

© 2014 International Anesthesia Research Society

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