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A&A Case Reports:
doi: 10.1097/ACC.0b013e3182a6d853
Case Reports: Case Report

Progressive Encephalomyelitis with Rigidity and Myoclonus: Anesthesia and Glycine Receptor Antibodies

Papadopoulou, Aikaterini MBBS; Samuels, Theophilus Luke MBBS; Dassanayake, Asitha MBBS; Spring, Colin MBBS; Willers, Johann MBChB; Uncles, David Roy MBBS

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Abstract

Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare autoimmune neurological condition. Antibodies targeting glycine receptors (GlyR) have been implicated in PERM. Because GlyR activity is enhanced by inhaled anesthetic drugs at clinically relevant concentrations, there is a theoretical possibility that these drugs may be less effective in the presence of GlyR antibodies. We describe a case of general anesthesia in a patient with PERM and GlyR antibodies. This patient did not demonstrate a clinically significant alteration in the behavioral effects of anesthesia using induction of anesthesia with sevoflurane and maintenance of anesthesia using sevoflurane and nitrous oxide.

© 2014 International Anesthesia Research Society

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