Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare autoimmune neurological condition. Antibodies targeting glycine receptors (GlyR) have been implicated in PERM. Because GlyR activity is enhanced by inhaled anesthetic drugs at clinically relevant concentrations, there is a theoretical possibility that these drugs may be less effective in the presence of GlyR antibodies. We describe a case of general anesthesia in a patient with PERM and GlyR antibodies. This patient did not demonstrate a clinically significant alteration in the behavioral effects of anesthesia using induction of anesthesia with sevoflurane and maintenance of anesthesia using sevoflurane and nitrous oxide.
From the Department of Anesthesia, Worthing Hospital, Worthing, United Kingdom.
Accepted for publication July 11, 2013.
The authors declare no conflicts of interest.
Address correspondence to Aikaterini Papadopoulou, MBBS, Department of Anesthesia, Worthing Hospital, Lyndhurst Road, Worthing, West Sussex, BN11 2DH, United Kingdom. Address e-mail to firstname.lastname@example.org.